Using Pre-Fatigue

[bigla2004]

All- I come from a powerlifting background, but now focusing on hypertrophy using FT for a number of months now. During some of my MR's with multiple sets, I've been using isolation exercises prior to compounds (pre-fatigue if you will). I wanted to get your take on the following:

Anyone have any experience using isolation moves first before compounds in their loading zig-zags? I know Scott mentions you can do this to change the stimulus and active the target muscle a bit better. I was wondering everyone's thoughts on doing iso's first on loading programatically throughout a blast to help activate the target muscle and really fatigue what you're trying to train.

Matt